Gene information
Official symbol AXL
Official full name AXL receptor tyrosine kinase
Gene type protein-coding gene
Chromosome19q13.2
Alias symbolUFO; JTK11; Tyro7; ARK
Gene familyReceptor tyrosine kinases; Fibronectin type III domain containing; V-set domain containing
Resources
Entrez Gene 558
HGNC HGNC:905
Ensembl ENSG00000167601
Vega OTTHUMG00000182727
UCSC uc010ehj.5
GO terms: 103 records
GO Description Category LogP Number of genes Detail
GO:0000302 response to reactive oxygen species GO Biological Processes -13.4775134 34 More
GO:0001775 cell activation GO Biological Processes -43.3738118 71 More
GO:0001776 leukocyte homeostasis GO Biological Processes -5.24665798 8 More
GO:0001818 negative regulation of cytokine production GO Biological Processes -48.9957481 97 More
GO:0001959 regulation of cytokine-mediated signaling pathway GO Biological Processes -13.0991884 33 More
GO:0002237 response to molecule of bacterial origin GO Biological Processes -48.4964960 93 More
GO:0002520 immune system development GO Biological Processes -15.2957169 80 More
GO:0002521 leukocyte differentiation GO Biological Processes -12.4650129 27 More
GO:0002683 negative regulation of immune system process GO Biological Processes -26.6415063 77 More
GO:0002694 regulation of leukocyte activation GO Biological Processes -32.0887020 60 More
GO:0002695 negative regulation of leukocyte activation GO Biological Processes -9.84552767 31 More
GO:0002696 positive regulation of leukocyte activation GO Biological Processes -27.9249645 47 More
GO:0004672 protein kinase activity GO Molecular Functions -2.03527804 36 More
GO:0005543 phospholipid binding GO Molecular Functions -6.61792344 45 More
GO:0006468 protein phosphorylation GO Biological Processes -5.36604576 56 More
GO:0006909 phagocytosis GO Biological Processes -7.82039874 17 More
GO:0006954 inflammatory response GO Biological Processes -86.5569367 100 More
GO:0006979 response to oxidative stress GO Biological Processes -17.6147653 58 More
GO:0007167 enzyme-linked receptor protein signaling pathway GO Biological Processes -26.8285253 93 More
GO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway GO Biological Processes -16.7048742 60 More
GO:0007276 gamete generation GO Biological Processes -2.03816629 18 More
GO:0007420 brain development GO Biological Processes -11.5572036 75 More
GO:0007548 sex differentiation GO Biological Processes -7.13021119 33 More
GO:0007596 blood coagulation GO Biological Processes -44.7281461 45 More
GO:0007599 hemostasis GO Biological Processes -44.1075001 45 More
GO:0008289 lipid binding GO Molecular Functions -15.8223476 88 More
GO:0009611 response to wounding GO Biological Processes -63.1714102 77 More
GO:0009617 response to bacterium GO Biological Processes -52.1760880 83 More
GO:0009991 response to extracellular stimulus GO Biological Processes -42.2178323 102 More
GO:0010035 response to inorganic substance GO Biological Processes -29.1720710 89 More
GO:0015629 actin cytoskeleton GO Cellular Components -8.47641494 26 More
GO:0016032 viral process GO Biological Processes -8.84449931 34 More
GO:0016301 kinase activity GO Molecular Functions -2.42130611 19 More
GO:0017022 myosin binding GO Molecular Functions -3.43892232 6 More
GO:0019058 viral life cycle GO Biological Processes -10.6409496 31 More
GO:0019199 transmembrane receptor protein kinase activity GO Molecular Functions -5.31743835 14 More
GO:0030097 hemopoiesis GO Biological Processes -14.1443585 71 More
GO:0030098 lymphocyte differentiation GO Biological Processes -7.22308617 17 More
GO:0031099 regeneration GO Biological Processes -17.4553316 23 More
GO:0031100 animal organ regeneration GO Biological Processes -17.1438387 17 More
GO:0031589 cell-substrate adhesion GO Biological Processes -10.7590108 32 More
GO:0031668 cellular response to extracellular stimulus GO Biological Processes -10.2327580 36 More
GO:0032496 response to lipopolysaccharide GO Biological Processes -45.257773 87 More
GO:0032680 regulation of tumor necrosis factor production GO Biological Processes -32.0729913 56 More
GO:0032720 negative regulation of tumor necrosis factor production GO Biological Processes -18.6356508 28 More
GO:0032940 secretion by cell GO Biological Processes -8.42144465 43 More
GO:0033674 positive regulation of kinase activity GO Biological Processes -29.8538991 87 More
GO:0034599 cellular response to oxidative stress GO Biological Processes -11.6255265 36 More
GO:0034614 cellular response to reactive oxygen species GO Biological Processes -9.93259803 24 More
GO:0042060 wound healing GO Biological Processes -56.2139708 65 More
GO:0042698 ovulation cycle GO Biological Processes -6.53718605 9 More
GO:0043523 regulation of neuron apoptotic process GO Biological Processes -14.5388618 39 More
GO:0043524 negative regulation of neuron apoptotic process GO Biological Processes -11.6647584 29 More
GO:0043549 regulation of kinase activity GO Biological Processes -36.8507249 123 More
GO:0044000 movement in host GO Biological Processes -9.40214314 25 More
GO:0044403 biological process involved in symbiotic interaction GO Biological Processes -18.5885778 29 More
GO:0045321 leukocyte activation GO Biological Processes -25.4958219 48 More
GO:0045619 regulation of lymphocyte differentiation GO Biological Processes -8.78322888 17 More
GO:0045621 positive regulation of lymphocyte differentiation GO Biological Processes -6.96534841 12 More
GO:0046649 lymphocyte activation GO Biological Processes -10.1732143 26 More
GO:0046660 female sex differentiation GO Biological Processes -6.37740711 11 More
GO:0046903 secretion GO Biological Processes -18.5147167 70 More
GO:0048511 rhythmic process GO Biological Processes -10.3377021 38 More
GO:0048534 hematopoietic or lymphoid organ development GO Biological Processes -16.4041704 79 More
GO:0048608 reproductive structure development GO Biological Processes -16.4007448 61 More
GO:0048771 tissue remodeling GO Biological Processes -15.8777137 28 More
GO:0048872 homeostasis of number of cells GO Biological Processes -12.0072872 22 More
GO:0050817 coagulation GO Biological Processes -44.4773041 45 More
GO:0050865 regulation of cell activation GO Biological Processes -40.6877761 71 More
GO:0050866 negative regulation of cell activation GO Biological Processes -13.9027363 39 More
GO:0050867 positive regulation of cell activation GO Biological Processes -31.2431659 51 More
GO:0050878 regulation of body fluid levels GO Biological Processes -57.9546976 69 More
GO:0051249 regulation of lymphocyte activation GO Biological Processes -22.6120519 46 More
GO:0051250 negative regulation of lymphocyte activation GO Biological Processes -7.76846228 25 More
GO:0051251 positive regulation of lymphocyte activation GO Biological Processes -20.2181987 37 More
GO:0051347 positive regulation of transferase activity GO Biological Processes -26.6059528 90 More
GO:0051701 biological process involved in interaction with host GO Biological Processes -10.6054189 28 More
GO:0051896 regulation of protein kinase B signaling GO Biological Processes -30.5149255 55 More
GO:0051897 positive regulation of protein kinase B signaling GO Biological Processes -23.7578366 39 More
GO:0060322 head development GO Biological Processes -11.995356 79 More
GO:0060759 regulation of response to cytokine stimulus GO Biological Processes -13.7003447 35 More
GO:0061458 reproductive system development GO Biological Processes -16.2516665 61 More
GO:0062197 cellular response to chemical stress GO Biological Processes -14.0979689 44 More
GO:0070301 cellular response to hydrogen peroxide GO Biological Processes -5.36006230 13 More
GO:0071216 cellular response to biotic stimulus GO Biological Processes -28.1549742 59 More
GO:0071219 cellular response to molecule of bacterial origin GO Biological Processes -28.3848077 56 More
GO:0071222 cellular response to lipopolysaccharide GO Biological Processes -26.0381191 52 More
GO:0071345 cellular response to cytokine stimulus GO Biological Processes -39.647808 70 More
GO:0071396 cellular response to lipid GO Biological Processes -37.0669488 98 More
GO:0071496 cellular response to external stimulus GO Biological Processes -17.0078490 52 More
GO:0140272 exogenous protein binding GO Molecular Functions -8.63789613 18 More
GO:0140352 export from cell GO Biological Processes -8.94733589 48 More
GO:1901214 regulation of neuron death GO Biological Processes -23.5458880 37 More
GO:1901215 negative regulation of neuron death GO Biological Processes -19.0527525 45 More
GO:1902105 regulation of leukocyte differentiation GO Biological Processes -18.8286876 32 More
GO:1902107 positive regulation of leukocyte differentiation GO Biological Processes -14.6775052 22 More
GO:1903131 mononuclear cell differentiation GO Biological Processes -9.35861236 21 More
GO:1903555 regulation of tumor necrosis factor superfamily cytokine production GO Biological Processes -32.3948799 57 More
GO:1903556 negative regulation of tumor necrosis factor superfamily cytokine production GO Biological Processes -18.2876323 28 More
GO:1903706 regulation of hemopoiesis GO Biological Processes -16.2759166 33 More
GO:1903708 positive regulation of hemopoiesis GO Biological Processes -14.6775052 22 More
GO:2000106 regulation of leukocyte apoptotic process GO Biological Processes -11.3593886 22 More
GO:2000107 negative regulation of leukocyte apoptotic process GO Biological Processes -6.57627568 8 More
Drug-Gene interaction
view
Related drugs: 25 records
Drug name Interaction type Source PMID View
bemcentinib inhibitor TTD view
bi-505 TTD view
bms-754807 DTC 19778024 view
bpi-9016 inhibitor ChemblInteractions view
cediranib DTC view
cenisertib DTC view
dasatinib DTC view
dovitinib DTC view
dubermatinib inhibitor TTD view
entrectinib DTC view
gefitinib DTC view
gilteritinib inhibitor ChemblInteractionsTTD 277756942851636026279055 view
glesatinib TTD view
goniothalamin DTC 25305718 view
gw843682x DTC view
hesperadin inhibitor DTC 19035792 view
ilorasertib DTC view
linifanib DTC view
osi-632 DTC view
pf-00562271 DTC view
r428 inhibitor ChemblInteractions view
sorafenib DTC view
tae-684 DTC view
tozasertib DTC view
vandetanib DTC view
Related studies: 2 records
Molecular factor Omics type Application Objective MI type Reference
tyrosine-protein kinase receptor UFO proteomics acute ST elevation myocardial infarction[diagnosis] acute ST elevation myocardial infarction Caldentey G et al. Eur Heart J Acute Cardiovasc Care. 2017
tyrosine-protein kinase receptor UFO proteomics left ventricular remodeling[prognosis (bad)] acute ST elevation myocardial infarction Caldentey G et al. Eur Heart J Acute Cardiovasc Care. 2017
All rights reserved: Soochow University Center for Systems Biology